| http://purl.uniprot.org/citations/17199038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17199038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17199038 | http://www.w3.org/2000/01/rdf-schema#comment | "The centromere is the chromosomal site that joins to microtubules during mitosis for proper segregation. Determining the location of a centromere-specific histone H3 called CENP-A at the centromere is vital for understanding centromere structure and function. Here, we report the identification of three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere. We provide evidence that such centromeric localization of hMis18 is essential for the subsequent recruitment of de novo-synthesized CENP-A. If any of the three is knocked down by RNAi, centromere recruitment of newly synthesized CENP-A is rapidly abolished, followed by defects such as misaligned chromosomes, anaphase missegregation, and interphase micronuclei. Tricostatin A, an inhibitor to histone deacetylase, suppresses the loss of CENP-A recruitment to centromeres in hMis18alpha RNAi cells. Telophase centromere chromatin may be primed or licensed by the hMis18 complex and RbAp46/48 to recruit CENP-A through regulating the acetylation status in the centromere."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2006.11.002"xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2006.11.002"xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Toyoda Y."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Toyoda Y."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Kiyomitsu T."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Kiyomitsu T."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Kokubu A."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/author | "Kokubu A."xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/pages | "17-30"xsd:string |
| http://purl.uniprot.org/citations/17199038 | http://purl.uniprot.org/core/pages | "17-30"xsd:string |