| http://purl.uniprot.org/citations/17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17199045 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt signaling regulates a variety of developmental processes in animals. Although the beta-catenin-dependent (canonical) pathway is known to control cell fate, a similar role for noncanonical Wnt signaling has not been established in mammals. Moreover, the intracellular cascades for noncanonical Wnt signaling remain to be elucidated. Here, we delineate a pathway in which Wnt3a signals through the Galpha(q/11) subunits of G proteins to activate phosphatidylinositol signaling and PKCdelta in the murine ST2 cells. Galpha(q/11)-PKCdelta signaling is required for Wnt3a-induced osteoblastogenesis in these cells, and PKCdelta homozygous mutant mice exhibit a deficit in embryonic bone formation. Furthermore, Wnt7b, expressed by osteogenic cells in vivo, induces osteoblast differentiation in vitro via the PKCdelta-mediated pathway; ablation of Wnt7b in skeletal progenitors results in less bone in the mouse embryo. Together, these results reveal a Wnt-dependent osteogenic mechanism, and they provide a potential target pathway for designing therapeutics to promote bone formation."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2006.11.003"xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Long F."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Tu X."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Nakayama K.I."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "McMahon A.P."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Joeng K.S."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Carroll T.J."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/author | "Rajagopal J."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/pages | "113-127"xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/title | "Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation."xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/17199045 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17199045 |
| http://purl.uniprot.org/citations/17199045 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG89-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE85-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEZ1-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A087WR05-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A0A1HAM8-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWF4-mappedCitation-17199045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199045 |