| http://purl.uniprot.org/citations/17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17199078 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial sodium channels (ENaC) are expressed in the apical membrane of high resistance Na(+) transporting epithelia and have a key role in regulating extracellular fluid volume and the volume of airway surface liquids. Maturation and activation of ENaC subunits involves furin-dependent cleavage of the ectodomain at two sites in the alpha subunit and at a single site within the gamma subunit. We now report that the serine protease prostasin further activates ENaC by inducing cleavage of the gamma subunit at a site distal to the furin cleavage site. Dual cleavage of the gamma subunit is predicted to release a 43-amino acid peptide. Channels with a gamma subunit lacking this 43-residue tract have increased activity due to a high open probability. A synthetic peptide corresponding to the fragment cleaved from the gamma subunit is a reversible inhibitor of endogenous ENaCs in mouse cortical-collecting duct cells and in primary cultures of human airway epithelial cells. Our results suggest that multiple proteases cleave ENaC gamma subunits to fully activate the channel."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m610636200"xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Sheng S."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Bruns J.B."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Hughey R.P."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Kleyman T.R."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Pilewski J.M."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Weisz O.A."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Carattino M.D."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/author | "Maarouf A.B."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/pages | "6153-6160"xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/title | "Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit."xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17199078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17199078 |
| http://purl.uniprot.org/citations/17199078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17199078 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNR9-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |
| http://purl.uniprot.org/uniprot/#_A2RS45-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |
| http://purl.uniprot.org/uniprot/#_A5X2V1-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |
| http://purl.uniprot.org/uniprot/#_H3BJC3-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |
| http://purl.uniprot.org/uniprot/#_H3BLI2-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |
| http://purl.uniprot.org/uniprot/#_H3BKC4-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |
| http://purl.uniprot.org/uniprot/#_H3BKP2-mappedCitation-17199078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17199078 |