| http://purl.uniprot.org/citations/17202194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17202194 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the family of WASP-family Verprolin homologous proteins (WAVEs) activate the Arp2/3 complex to induce actin polymerization. The WAVE family comprises three proteins, namely, WAVE1, WAVE2 and WAVE3. Among them, WAVE2 is crucial for activation of the Arp2/3 complex for the formation of branched actin filaments in lamellipodia. Activation of mitogen-activated protein (MAP) kinase signalling results in the phosphorylation of the WAVE family proteins; however, which of the three WAVE proteins is phosphorylated is unclear. We found that in vitro WAVE2 is directly phosphorylated by a MAP kinase, i.e. extracellular signal-regulated kinase (ERK) 2. The proline-rich region and the verprolin, cofilin and acidic (VCA) region of WAVE2 were phosphorylated. Interestingly, the phosphorylated VCA region had a higher affinity for the Arp2/3 complex. However, the phosphorylation of the VCA region resulted in reduced induction of Arp2/3-mediated actin polymerization in vitro. The role of the phosphorylation of the proline-rich region was not determined."xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvm034"xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/author | "Suetsugu S."xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/author | "Yamazaki D."xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/author | "Nakanishi O."xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/pages | "319-325"xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/title | "Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex."xsd:string |
| http://purl.uniprot.org/citations/17202194 | http://purl.uniprot.org/core/volume | "141"xsd:string |
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