| http://purl.uniprot.org/citations/17202326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17202326 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulated inflammation is a complication of type 2 diabetes (T2D). In this study, we show that augmented LPS-induced TNF-alpha production by resident peritoneal macrophages (PerMphi) in type 2 diabetic (db/db) mice is dependent on elevated glucose and requires p38 MAPK. Intraperitoneal LPS administered to db/db and nondiabetic (db/+) mice induced 3- and 4-fold more TNF-alpha in the peritoneum and serum, respectively, of db/db mice as compared with db/+ mice. Examination of the TLR-4/MD2 complex and CD14 expression showed no difference between db/db and db/+ PerMphi. Ex vivo stimulation of PerMphi with LPS produced a similar 3-fold increase in TNF-alpha production in db/db PerMphi when compared with db/+ PerMphi. PerMphi isolated from db/+ mice incubated in high glucose (4 g/L) medium for 12 h produced nearly 2-fold more TNF-alpha in response to LPS than PerMphi incubated in normal glucose medium (1 g/L). LPS-dependent stimulation of PI3K activity, ERK1/2 activation, and p38 kinase activity was greater in PerMphi from db/db mice as compared with db/+ mice. Only inhibition of p38 kinase blocked LPS-induced TNF-alpha production in PerMphi from db/db mice. Taken together, these data indicate that augmented TNF-alpha production induced by LPS in macrophages during diabetes is due to hyperglycemia and increased LPS-dependent activation of p38 kinase."xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.2.663"xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/author | "Kramer J.M."xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/author | "Freund G.G."xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/author | "O'Connor J.C."xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/author | "Sherry C.L."xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/pages | "663-670"xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/title | "Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK."xsd:string |
| http://purl.uniprot.org/citations/17202326 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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