| http://purl.uniprot.org/citations/17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17202339 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4(+) T cells promote effective CD8(+) T cell-mediated immunity, but the timing and mechanistic details of such help remain controversial. Furthermore, the extent to which innate stimuli act independently of help in enhancing CD8(+) T cell responses is also unresolved. Using a noninfectious vaccine model in immunocompetent mice, we show that even in the presence of innate stimuli, CD4(+) T cell help early after priming is required for generating an optimal pool of functional memory CD8(+) T cells. CD4(+) T cell help increased the size of a previously unreported population of IL-6Ralpha(high)IL-7Ralpha(high) prememory CD8(+) T cells shortly after priming that showed a survival advantage in vivo and contributed to the majority of functional memory CD8(+) T cells after the contraction phase. In accord with our recent demonstration of chemokine-guided recruitment of naive CD8(+) T cells to sites of CD4(+) T cell-dendritic cell interactions, the generation of IL-6Ralpha(high)IL-7Ralpha(high) prememory as well as functional memory CD8(+) T cells depended on the early postvaccination action of the inflammatory chemokines CCL3 and CCL4. Together, these findings support a model of CD8(+) T cell memory cell differentiation involving the delivery of key signals early in the priming process based on chemokine-guided attraction of naive CD8(+) T cells to sites of Ag-driven interactions between TLR-activated dendritic cells and CD4(+) T cells. They also reveal that elevated IL-6Ralpha expression by a subset of CD8(+) T cells represents an early imprint of CD4(+) T cell helper function that actively contributes to the survival of activated CD8(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.2.778"xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/author | "Castellino F."xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/author | "Germain R.N."xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/pages | "778-787"xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/title | "Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/17202339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17202339 |
| http://purl.uniprot.org/citations/17202339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17202339 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF1-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_A2NV53-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRC2-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_P10855-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_P16872-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q5QNW0-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q8BGR0-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_P22272-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q3U3Z0-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q3U6F9-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q3URV7-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q5FW78-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |
| http://purl.uniprot.org/uniprot/#_Q8C9W4-mappedCitation-17202339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17202339 |