| http://purl.uniprot.org/citations/17202846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17202846 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.org/dc/terms/identifier | "doi:10.1038/emm.2006.82"xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Choi Y.H."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Lee H.S."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Kim L.H."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Park B.L."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Shin H.D."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/author | "Cheong H.S."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/pages | "694-702"xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/title | "Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance."xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/17202846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17202846 |
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