| http://purl.uniprot.org/citations/17204408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17204408 | http://www.w3.org/2000/01/rdf-schema#comment | "ERM (ezrin/radixin/moesin) proteins are organizers of apical actin cortical layer in general. We previously reported that the knockout of radixin resulted in Rdx(-/-) mice with displacement/loss of the canalicular transporter Mrp2, giving rise to Dubin-Johnson syndrome-like conjugated hyperbilirubinemia in the mixed genetic background (C57BL/6-129/Sv) (Kikuchi, et al. (2002) Nature Genetics 31, 320-325). However, when these mice were kept under mixed genetic background for years (late mixed backgrounds; LMB), the conjugated hyperbilirubinemia gradually became inconspicuous, while evidence of liver injury increased. We examined the effect of genetic background by backcrossing LMB Rdx(-/-) mice to C57BL/6 and 129/Sv wild type mice with the result that the Rdx(-/-) congenic mice regained hyperbilirubinemia with reduced hepatocellular damage. As revealed by immunofluorescence and western blots, the localization/expression of apical transporters, Mrp2, CD26, P-gps, and Bsep were not influenced by backcrossing, though those of a basolateral transporter, Mrp3, were strikingly increased by backcrossing."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2006.11.005"xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Itoh N."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Tsukita S."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Tamura A."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Kikuchi S."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Yamagishi H."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Hata M."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Fukumoto K."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/author | "Tsukita S.'"xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/pages | "298-306"xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/title | "Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3."xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://purl.uniprot.org/core/volume | "1772"xsd:string |
| http://purl.uniprot.org/citations/17204408 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17204408 |
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