| http://purl.uniprot.org/citations/17206146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17206146 | http://www.w3.org/2000/01/rdf-schema#comment | "B and T lymphocyte attenuator (BTLA) is a negative regulator of T cell activation, but its function in vivo is not well characterized. Here we show that mice deficient in full-length BTLA or its ligand, herpesvirus entry mediator, had increased number of memory CD8(+) T cells. The memory CD8(+) T cell phenotype resulted from a T cell-intrinsic perturbation of the CD8(+) T cell pool. Naive BTLA-deficient CD8(+) T cells were more efficient than wild-type cells at generating memory in a competitive antigen-specific system. This effect was independent of the initial expansion of the responding antigen-specific T cell population. In addition, BTLA negatively regulated antigen-independent homeostatic expansion of CD4(+) and CD8(+) T cells. These results emphasize two central functions of BTLA in limiting T cell activity in vivo."xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1418"xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/author | "Kaye J."xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/author | "Fu Y.X."xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/author | "Boyman O."xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/author | "Krieg C."xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/pages | "162-171"xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/title | "B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation."xsd:string |
| http://purl.uniprot.org/citations/17206146 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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