| http://purl.uniprot.org/citations/17206937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17206937 | http://www.w3.org/2000/01/rdf-schema#comment | "We have investigated the ability of apoE (apolipoprotein E) to participate in the biogenesis of HDL (high-density lipoprotein) particles in vivo using adenovirus-mediated gene transfer in apoA-I-/- (apolipoprotein A-I) or ABCA1-/-(ATP-binding cassette A1) mice. Infection of apoA-I-/-mice with 2x10(9) pfu (plaque-forming units) of an apoE4-expressing adenovirus increased both HDL and the triacylglycerol-rich VLDL (very-low-density lipoprotein)/IDL (intermediate-density lipoprotein)/LDL (low-density lipoprotein) fraction and generated discoidal HDL particles. ABCA1-/-mice treated similarly failed to form HDL particles, suggesting that ABCA1 is essential for the generation of apoE-containing HDL. Combined infection of apoA-I-/-mice with a mixture of adenoviruses expressing both apoE4 (2x10(9) pfu) and human LCAT (lecithin:cholesterol acyltransferase) (5x10(8) pfu) cleared the triacylglycerol-rich lipoproteins, increased HDL and converted the discoidal HDL into spherical HDL. Similarly, co-infection of apoE-/-mice with apoE4 and human LCAT corrected the hypercholesterolaemia and generated spherical particles, suggesting that LCAT is essential for the maturation of apoE-containing HDL. Overall, the findings indicate that apoE has a dual functionality. In addition to its documented functions in the clearance of triacylglycerol-rich lipoproteins, it participates in the biogenesis of HDL-sized apoE-containing particles. HDL particles generated by this pathway may account at least for some of the atheroprotective functions of apoE."xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20061048"xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/author | "Zannis V.I."xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/author | "Kypreos K.E."xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/pages | "359-367"xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/title | "Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT."xsd:string |
| http://purl.uniprot.org/citations/17206937 | http://purl.uniprot.org/core/volume | "403"xsd:string |
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