DESCRIBE <http://purl.uniprot.org/citations/17208599>

Subject	Predicate	Object
http://purl.uniprot.org/citations/17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17208599	http://www.w3.org/2000/01/rdf-schema#comment	" Background Histamine is a potent mediator of itch in humans, yet histamine H(1) receptor antagonists have been shown to be of limited use in the treatment of certain chronic pruritic diseases. The histamine H(4) receptor is a recently described histamine receptor, expressed on hematopoietic cells, linked to the pathology of allergy and asthma. Objective The contribution of the novel histamine H(4) receptor to histaminergic and allergic pruritus was investigated. Results Histamine and a selective histamine H(4) receptor agonist caused scratching responses in mice, which were almost completely attenuated in histamine H(4) receptor knockout mice or by pretreatment with the selective histamine H(4) receptor antagonist, JNJ 7777120. Pruritus induced by allergic mechanisms was also potently inhibited with histamine H(4) receptor antagonist treatment or in histamine H(4) receptor knockout mice. In all cases, the inhibitory effect of histamine H(4) receptor antagonist was greater than those observed with histamine H(1) receptor antagonists. The histamine H(4) receptor-mediated pruritus was shown to be independent of mast cells or other hematopoietic cells and may result from actions on peripheral neurons. Conclusion These results demonstrate that the histamine H(4) receptor is involved in pruritic responses in mice to a greater extent than the histamine H(1) receptor. Clinical implications Histamine H(4) receptor antagonists may have therapeutic utility for treating chronic pruritic diseases in humans where histamine H(1) receptor antagonists are not effective."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.org/dc/terms/identifier	"doi:10.1016/j.jaci.2006.08.034"xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/author	"Desai P.J."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/author	"Karlsson L."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/author	"Thurmond R.L."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/author	"Williams K.N."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/author	"Dunford P.J."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/author	"McQueen D."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/date	"2007"xsd:gYear
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/name	"J Allergy Clin Immunol"xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/pages	"176-183"xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/title	"Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus."xsd:string
http://purl.uniprot.org/citations/17208599	http://purl.uniprot.org/core/volume	"119"xsd:string
http://purl.uniprot.org/citations/17208599	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/17208599
http://purl.uniprot.org/citations/17208599	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/17208599
http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/#_B2ZGH2-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/#_B2ZGH3-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/#_Q2M2N7-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/#_P05532-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/#_Q91ZY2-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/#_Q3ULJ6-mappedCitation-17208599	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/Q3ULJ6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17208599
http://purl.uniprot.org/uniprot/P05532	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17208599