| http://purl.uniprot.org/citations/17209125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17209125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17209125 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon the incidence of DNA stress, the ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signaling kinases activate a transient cell cycle arrest that allows cells to repair DNA before proceeding into mitosis. Although the ATM-ATR pathway is highly conserved over species, the mechanisms by which plant cells stop their cell cycle in response to the loss of genome integrity are unclear. We demonstrate that the cell cycle regulatory WEE1 kinase gene of Arabidopsis thaliana is transcriptionally activated upon the cessation of DNA replication or DNA damage in an ATR- or ATM-dependent manner, respectively. In accordance with a role for WEE1 in DNA stress signaling, WEE1-deficient plants showed no obvious cell division or endoreduplication phenotype when grown under nonstress conditions but were hypersensitive to agents that impair DNA replication. Induced WEE1 expression inhibited plant growth by arresting dividing cells in the G2-phase of the cell cycle. We conclude that the plant WEE1 gene is not rate-limiting for cycle progression under normal growth conditions but is a critical target of the ATR-ATM signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints, coupling mitosis to DNA repair in cells that suffer DNA damage."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.org/dc/terms/identifier | "doi:10.1105/tpc.106.045047"xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.org/dc/terms/identifier | "doi:10.1105/tpc.106.045047"xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Beeckman T."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Beeckman T."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Babiychuk E."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Babiychuk E."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Inze D."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Inze D."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Kushnir S."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Kushnir S."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Joubes J."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Joubes J."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Verkest A."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Verkest A."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "de Veylder L."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "de Veylder L."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "van der Schueren E."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "van der Schueren E."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Cools T."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Cools T."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Corellou F."xsd:string |
| http://purl.uniprot.org/citations/17209125 | http://purl.uniprot.org/core/author | "Corellou F."xsd:string |