| http://purl.uniprot.org/citations/17210687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17210687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17210687 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we observed loss of heterozygosity (LOH) in human chromosomal fragment 6q25.1 in sporadic lung cancer patients. LOH was observed in 65% of the 26 lung tumors examined and was narrowed down to a 2.2-Mb region. Single-nucleotide polymorphism (SNP) analysis of genes located within this region identified a candidate gene, termed p34. This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or dJ281H8.1, carries an A/G nonsynonymous SNP at codon 106, which alters the amino acid from lysine to arginine. Nearly 73% of heterozygous lung cancer tissues with LOH and the A/G SNP also exhibited loss of the A allele. In vitro clonogenic and in vivo nude mouse studies showed that overexpression of the A allele exerts tumor suppressor function compared with the G allele. p34 is located within a recently mapped human lung cancer susceptibility locus, and association of the p34 A/G SNP was tested among these families. No significant association between the less frequent G allele and lung cancer susceptibility was found. Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-2723"xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-2723"xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Gazdar A."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Gazdar A."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Minna J."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Minna J."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wiest J.S."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Wiest J.S."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Amos C.I."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Amos C.I."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Bierut L.J."xsd:string |
| http://purl.uniprot.org/citations/17210687 | http://purl.uniprot.org/core/author | "Bierut L.J."xsd:string |