| http://purl.uniprot.org/citations/17213291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17213291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17213291 | http://www.w3.org/2000/01/rdf-schema#comment | "Fc receptor-like proteins (FcRLs) are a growing family of molecules homologous to FcgammaRI. Whereas all 7 previously reported Fc receptor homologs are expressed by B cells, here we report a new receptor, FcRL6, that is expressed by cytolytic cells including natural killer (NK) cells and effector and effector-memory CD8(+) T cells. FcRL6 contains a novel cytoplasmic cysteine-rich motif and recruits SHP-2 through a phosphorylated ITIM, indicating a potential signaling function in effector lymphocytes. In vitro, FcRL6 does not greatly influence NK-cell or CD8(+) T-cell-mediated cytotoxicity and has minimal impact on cytokine secretion. However, FcRL6 expression among T lymphocytes is greatly expanded in human immunodeficiency virus type 1 (HIV-1)-infected individuals, and includes not only effector and effector-memory CD8(+) T cells but also populations of CD4(+) T cells. Expansion of FcRL6-positive lymphocytes is not related to viral load, but is indicative of the dysregulated expansion of terminally differentiated effector lymphocyte populations in response to chronic HIV-1 infection and may serve as an important marker for chronic immune activation and for tracking the generation of effector cells following immune stimulation."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-06-030023"xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-06-030023"xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Presti R.M."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Presti R.M."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Wilson T.J."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Wilson T.J."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Overton E.T."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Overton E.T."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Tassi I."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/author | "Tassi I."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/pages | "3786-3793"xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/pages | "3786-3793"xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/title | "FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/17213291 | http://purl.uniprot.org/core/title | "FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection."xsd:string |