| http://purl.uniprot.org/citations/17214962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17214962 | http://www.w3.org/2000/01/rdf-schema#comment | "Bile acids, which have been implicated in gastrointestinal-tract cell carcinogenesis, share properties with tumor promoters in that both affect signal transduction pathways responsible for cell proliferation and apoptosis. In the present study, we demonstrate that EGFR-ERK1/2 is activated following treatment of AGS human gastric carcinoma cells with bile acids. EGFR phosphoactivation is ligand-dependent, since treatment of cells with HB-EGF antisera or CM197 (a selective inhibitor of HB-EGF) markedly inhibits deoxycholate (DC)-promoted activation. Membrane-type bile acid receptor (M-BAR)/TGR5 is a recently identified G-protein-coupled receptor (GPCR). In AGS cells, siRNAs that target M-BAR suppress DC-induced phosphorylation of EGFR. Furthermore, introduction of siRNAs targeting ADAM17 transcripts resulted in suppression of DC-induced activation of EGFR and ERK1/2. These results suggest that in AGS cells, DC transactivates EGFR through M-BAR- and ADAM/HB-EGF-dependent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.12.168"xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/author | "Yasuda H."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/author | "Ohnishi H."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/author | "Hirata S."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/author | "Mashima H."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/author | "Yoshiba M."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/pages | "154-159"xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/title | "Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://purl.uniprot.org/core/volume | "354"xsd:string |
| http://purl.uniprot.org/citations/17214962 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17214962 |
| http://purl.uniprot.org/citations/17214962 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17214962 |
| http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-17214962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17214962 |
| http://purl.uniprot.org/uniprot/#_A8K2T7-mappedCitation-17214962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17214962 |
| http://purl.uniprot.org/uniprot/#_A0A068JCC9-mappedCitation-17214962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17214962 |
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| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F1-mappedCitation-17214962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17214962 |
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