| http://purl.uniprot.org/citations/17218259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17218259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17218259 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule behavior changes during the cell cycle and during spindle assembly. However, it remains unclear how these changes are regulated and coordinated. We describe a complex that targets the Protein Phosphatase 2A holoenzyme (PP2A) to centrosomes in C. elegans embryos. This complex includes Regulator of Spindle Assembly 1 (RSA-1), a targeting subunit for PP2A, and RSA-2, a protein that binds and recruits RSA-1 to centrosomes. In contrast to the multiple functions of the PP2A catalytic subunit, RSA-1 and RSA-2 are specifically required for microtubule outgrowth from centrosomes and for spindle assembly. The centrosomally localized RSA-PP2A complex mediates these functions in part by regulating two critical mitotic effectors: the microtubule destabilizer KLP-7 and the C. elegans regulator of spindle assembly TPXL-1. By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.10.050"xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.10.050"xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Dammermann A."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Dammermann A."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "MacLeod I."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "MacLeod I."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Mueller-Reichert T."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Mueller-Reichert T."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Quintin S."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Quintin S."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Schlaitz A.L."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Schlaitz A.L."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Shevchenko A."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Shevchenko A."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Srayko M."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Srayko M."xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/17218259 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |