| http://purl.uniprot.org/citations/17220269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17220269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17220269 | http://www.w3.org/2000/01/rdf-schema#comment | "Amt proteins are ubiquitous channels for the conduction of ammonia in archaea, eubacteria, fungi, and plants. In Escherichia coli, previous studies have indicated that binding of the PII signal transduction protein GlnK to the ammonia channel AmtB regulates the channel thereby controlling ammonium influx in response to the intracellular nitrogen status. Here, we describe the crystal structure of the complex between AmtB and GlnK at a resolution of 2.5 A. This structure of PII in a complex with one of its targets reveals physiologically relevant conformations of both AmtB and GlnK. GlnK interacts with AmtB almost exclusively via a long surface loop containing Y51 (T-loop), the tip of which inserts deeply into the cytoplasmic pore exit, blocking ammonia conduction. Y51 of GlnK is also buried in the pore exit, explaining why uridylylation of this residue prevents complex formation."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0610348104"xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0610348104"xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Bullough P.A."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Bullough P.A."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Conroy M.J."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Conroy M.J."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Winkler F.K."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Winkler F.K."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Li X.D."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Li X.D."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Merrick M."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Merrick M."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Durand A."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Durand A."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Lupo D."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/author | "Lupo D."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/pages | "1213-1218"xsd:string |
| http://purl.uniprot.org/citations/17220269 | http://purl.uniprot.org/core/pages | "1213-1218"xsd:string |