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| http://purl.uniprot.org/citations/17220887 | http://www.w3.org/2000/01/rdf-schema#comment | "Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane motions. The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane, a sheet of extracellular matrix that overlies the cochlea's sensory epithelium. The tectorial membrane contains radially organized collagen fibrils that are imbedded in an unusual striated-sheet matrix formed by two glycoproteins, alpha-tectorin (Tecta) and beta-tectorin (Tectb). In Tectb(-/-) mice the structure of the striated-sheet matrix is disrupted. Although these mice have a low-frequency hearing loss, basilar-membrane and neural tuning are both significantly enhanced in the high-frequency regions of the cochlea, with little loss in sensitivity. These findings can be attributed to a reduction in the acting mass of the tectorial membrane and reveal a new function for this structure in controlling interactions along the cochlea."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1828"xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/author | "Goodyear R.J."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/author | "Legan P.K."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/author | "Richardson G.P."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/author | "Russell I.J."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/author | "Lukashkina V.A."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/author | "Lukashkin A.N."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/pages | "215-223"xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/title | "Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane."xsd:string |
| http://purl.uniprot.org/citations/17220887 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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