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| http://purl.uniprot.org/citations/17222572 | http://www.w3.org/2000/01/rdf-schema#comment | "With help of a hCD25 reporter controlled by pre-T cell receptor alpha (Ptcra) regulatory elements, T cell precursors were identified in peripheral blood. Sca-1(+)IL-7Ralpha(+)Flt3(-) precursors that were c-kit(lo)Thy-1(hi) generated T lineage cells when cultured on OP9-DL1 stromal cells and upon transfer into Rag2(-/-)Il2rg(-/-) mice. No B cells were generated in vivo and only few in vitro. These cells, which we call circulating T cell progenitors (CTP), were found at the same frequency in Foxn1(nu/nu) thymus-deficient mice and wild-type mice, indicating that they were pre-rather than postthymic. Inhibition of Notch-dependent transcription in vivo reduced the frequency of intrathymic early T cell progenitors (ETP), but not CTP, indicating that the latter are less Notch dependent. Thus, CTP represent T lineage-committed T cell precursors linking extrathymic with intrathymic lymphopoiesis in adult mice."xsd:string |
| http://purl.uniprot.org/citations/17222572 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.12.004"xsd:string |
| http://purl.uniprot.org/citations/17222572 | http://purl.uniprot.org/core/author | "Krueger A."xsd:string |
| http://purl.uniprot.org/citations/17222572 | http://purl.uniprot.org/core/author | "von Boehmer H."xsd:string |
| http://purl.uniprot.org/citations/17222572 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17222572 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17222572 | http://purl.uniprot.org/core/pages | "105-116"xsd:string |
| http://purl.uniprot.org/citations/17222572 | http://purl.uniprot.org/core/title | "Identification of a T lineage-committed progenitor in adult blood."xsd:string |
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