| http://purl.uniprot.org/citations/17224401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17224401 | http://www.w3.org/2000/01/rdf-schema#comment | "In the olfactory system of Drosophila, 50 functional classes of sensory receptor neurons (ORNs) project in a highly organized fashion into the CNS, where they sort out from one another and converge into distinct synaptic glomeruli. We identified the transmembrane molecule Semaphorin-1a (Sema-1a) as an essential component to ensure glomerulus-specific axon segregation. Removal of sema-1a in ORNs does not affect the pathfinding toward their target area but disrupts local axonal convergence into a single glomerulus, resulting in two distinct targeting phenotypes: axons either intermingle with adjacent ORN classes or segregate according to their odorant receptor identity into ectopic sites. Differential Sema-1a expression can be detected among neighboring glomeruli, and mosaic analyses show that sema-1a functions nonautonomously in ORN axon sorting. These findings provide insights into the mechanism by which afferent interactions lead to synaptic specificity in the olfactory system."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.12.024"xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/author | "Schulte C."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/author | "Hummel T."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/author | "Seidl S."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/author | "Kuhlmann B."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/author | "Lattemann M."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/author | "Zierau A."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/pages | "169-184"xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/title | "Semaphorin-1a controls receptor neuron-specific axonal convergence in the primary olfactory center of Drosophila."xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/17224401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17224401 |
| http://purl.uniprot.org/citations/17224401 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17224401 |
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