| http://purl.uniprot.org/citations/17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17226113 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, significant associations between common variants of the transcription factor 7-like 2 gene ( TCF7L2) and type 2 diabetes have been reported. This study was designed to replicate the reported associations of the two highly correlated (r (2)=0.86) TCF7L2 single nucleotide polymorphisms rs12255372 and rs7903146 with type 2 diabetes in a case-control study of 2369 MONICA/KORA participants (678 cases/1691 controls from Augsburg, Germany). To further investigate the pathogenic mechanism underlying these associations, we extended our analyses to the metabolic syndrome (IDF, NCEP definitions) and its components in a population-based study comprising 1404 male and female KORA participants aged 55-74 years. Results of our analyses strongly confirmed the minor T alleles as risk variants for type 2 diabetes (rs7903146: OR (TvsC) [95% CI]=1.36 [1.18;1.58], p=0.00003, and rs12255372: OR (TvsG) [95% CI]=1.31 [1.13;1.51], p=0.0003). Moreover, the T allele at rs7903146 was inversely associated with log-transformed, HOMA-%B (beta=-0.07, p=0.005) as a measure of basal insulin secretion, and log-transformed fasting insulin (beta=-0.06, p=0.02). No association was found with insulin resistance (HOMA-IR) and the metabolic syndrome. These findings support replication evidence that TCF7L2 variants increase type 2 diabetes risk. TCF7L2 may primarily affect pancreatic beta cell function."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.org/dc/terms/identifier | "doi:10.1055/s-2007-957345"xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Meisinger C."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Wichmann H.E."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Grallert H."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Illig T."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Herder C."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Huth C."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Rathmann W."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Kolz M."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/author | "Marzi C."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/name | "Horm Metab Res"xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/pages | "46-52"xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/title | "Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys."xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/17226113 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17226113 |
| http://purl.uniprot.org/citations/17226113 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17226113 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17226113 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17226113 |
| http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17226113 |
| http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17226113 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17226113 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTN9-mappedCitation-17226113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17226113 |