| http://purl.uniprot.org/citations/17227833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17227833 | http://www.w3.org/2000/01/rdf-schema#comment | "TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice. Activation of Hh signaling in thymocytes in vivo by expression of a transgenic transcriptional-activator form of Gli2 (Gli2DeltaN(2)) changed the outcome of TCR ligation at many stages of thymocyte development, allowing self-reactive cells to escape clonal deletion; reducing transgenic TCR-mediated positive selection; reducing the ratio of CD4/CD8 single-positive (SP) cells; and reducing cell surface CD5 expression. In contrast, in the Shh(-/-) thymus the ratio of CD4/CD8 cells and both positive and negative selection of a transgenic TCR were increased, demonstrating that Shh does indeed influence TCR repertoire selection and the transition from double-positive (DP) to SP cell in a physiological situation. In peripheral T cells, Gli2DeltaN(2) expression attenuated T-cell activation and proliferation, by a mechanism upstream of ERK phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-07-037655"xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Crompton T."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Dyson J."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Drakopoulou E."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Cebecauer M."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Outram S.V."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Hager-Theodorides A.L."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Shah D.K."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/author | "Rowbotham N.J."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/pages | "3757-3766"xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/title | "Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17227833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17227833 |
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| http://purl.uniprot.org/uniprot/#_Q8C765-mappedCitation-17227833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17227833 |
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