| http://purl.uniprot.org/citations/17229149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17229149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17229149 | http://www.w3.org/2000/01/rdf-schema#comment | "cGMP secretion from cells can be mediated by ATP-binding cassette (ABC) transporters ABCC4, ABCC5, and ABCC11. Indirect evidence suggests that ABCC4 and ABCC5 contribute to cGMP transport by erythrocytes. We have re-investigated the issue using erythrocytes from wild-type and transporter knockout mice. Murine wild-type erythrocyte vesicles transported cGMP with an apparent Km that was 100-fold higher than their human counterparts, the apparent Vmax being similar. Whereas cGMP transport into human vesicles was efficiently inhibited by the ABCC4-specific substrate prostaglandin E1, cGMP transport into mouse vesicles was inhibited equally by Abcg2 and Abcc4 inhibitors/substrates. Similarly, cGMP transport into vesicles from Abcc4-/- and Abcg2-/-mice was 42% and 51% of that into wild-type mouse vesicles, respectively, whereas cGMP transport into vesicles from Abcc4(-/-)/Abcg2(-/-) mice was near background. The knockout mice were used to show that Abcg2-mediated cGMP transport occurred with lower affinity but higher Vmax than Abcc4-mediated transport. Involvement of Abcg2 in cGMP transport by Abcc4-/-erythrocyte vesicles was supported by higher transport at pH 5.5 than at pH 7.4, a characteristic of Abcg2-mediated transport. The relative contribution of ABCC4/Abcc4 and ABCG2/Abcg2 in cGMP transport was confirmed with a new inhibitor of ABCC4 transport, the protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2006.05591.x"xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2006.05591.x"xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Ono N."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Ono N."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Borst P."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Borst P."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Wijnholds J."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Wijnholds J."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Schuetz J.D."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Schuetz J.D."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Scheffer G.L."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Scheffer G.L."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "van der Heijden I."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "van der Heijden I."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "de Haas M."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "de Haas M."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Hundscheid S.L."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Hundscheid S.L."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Wielinga P.R."xsd:string |
| http://purl.uniprot.org/citations/17229149 | http://purl.uniprot.org/core/author | "Wielinga P.R."xsd:string |