| http://purl.uniprot.org/citations/17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17229887 | http://www.w3.org/2000/01/rdf-schema#comment | "Using phage display, we identified Na+/H+ exchanger regulatory factor (NHERF)-2 as a novel binding partner for the cadherin-associated protein, beta-catenin. We showed that the second of two PSD-95/Dlg/ZO-1 (PDZ) domains of NHERF interacts with a PDZ-binding motif at the very carboxy terminus of beta-catenin. N-cadherin expression has been shown to induce motility in a number of cell types. The first PDZ domain of NHERF is known to bind platelet-derived growth factor-receptor beta (PDGF-Rbeta), and the interaction of PDGF-Rbeta with NHERF leads to enhanced cell spreading and motility. Here we show that beta-catenin and N-cadherin are in a complex with NHERF and PDGF-Rbeta at membrane ruffles in the highly invasive fibrosarcoma cell line HT1080. Using a stable short hairpin RNA system, we showed that HT1080 cells knocked down for either N-cadherin or NHERF had impaired ability to migrate into the wounded area in a scratch assay, similar to cells treated with a PDGF-R kinase inhibitor. Cells expressing a mutant NHERF that is unable to associate with beta-catenin had increased stress fibers, reduced lamellipodia, and impaired cell migration. Using HeLa cells, which express little to no PDGF-R, we introduced PDGF-Rbeta and showed that it coimmunoprecipitates with N-cadherin and that PDGF-dependent cell migration was reduced in these cells when we knocked-down expression of N-cadherin or NHERF. These studies implicate N-cadherin and beta-catenin in cell migration via PDGF-R-mediated signaling through the scaffolding molecule NHERF."xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-10-0960"xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/author | "Johnson K.R."xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/author | "Wheelock M.J."xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/author | "Wahl J.K."xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/author | "Theisen C.S."xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/pages | "1220-1232"xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/title | "NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility."xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/17229887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17229887 |
| http://purl.uniprot.org/citations/17229887 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17229887 |
| http://purl.uniprot.org/uniprot/#_Q15599-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_A0A384NYY3-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_B2ZRE2-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
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| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_B4DL06-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_P01127-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_B5BU28-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_G9GAG7-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |
| http://purl.uniprot.org/uniprot/#_C9J126-mappedCitation-17229887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17229887 |