| http://purl.uniprot.org/citations/17234681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17234681 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns. IL-18 was constitutively expressed in the retina in C57BL/6 mice, but expression transiently dropped on Day 17 after birth in mice exposed to 75% oxygen for 5 days between Days 7 and 12. Coincident with the IL-18 reduction in oxygen-treated mice, vascular endothelial growth factor was expressed in the retina, and OIR developed. By Day 24, NV in the retina had regressed to normal levels. By contrast, IL-18 knockout mice, exposed to elevated oxygen concentrations, developed more severe OIR on Day 17, and it is important that this persisted until Day 24. This suggested that IL-18 negatively regulated retinal NV. To investigate this further, we administrated recombinant IL-18 to C57BL/6 mice during the development of OIR but found no significant inhibition of retinopathy. However, when IL-18-binding protein was administered during the OIR recovery phase to neutralize endogenous IL-18, OIR was still apparent on Day 24. We therefore concluded that IL-18 regulates pathogenic retinal NV by promoting its regression rather than inhibiting its development. This suggests some useful, new approaches to treating retinopathy in humans."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0506342"xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Hata Y."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Ishibashi T."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Yoshimura T."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Ikeda Y."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Jo Y.J."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Qiao H."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Sassa Y."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Sonoda K.H."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Tsutsumi-Miyahara C."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/author | "Hijioka K."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/pages | "1012-1021"xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/title | "Interleukin-18 regulates pathological intraocular neovascularization."xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17234681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17234681 |
| http://purl.uniprot.org/citations/17234681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17234681 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STF5-mappedCitation-17234681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234681 |
| http://purl.uniprot.org/uniprot/#_A0PJ18-mappedCitation-17234681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234681 |
| http://purl.uniprot.org/uniprot/#_P70380-mappedCitation-17234681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234681 |
| http://purl.uniprot.org/uniprot/#_K3W4N2-mappedCitation-17234681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234681 |