| http://purl.uniprot.org/citations/17234765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17234765 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent progress in the development of inhibitors of protein-protein interactions has opened the door for developing drugs that act by novel and selective mechanisms. Building on that work, we designed a small-molecule inhibitor of the Wnt signaling pathway, which is aberrantly activated across a wide range of human tumors. The compound, named FJ9, disrupts the interaction between the Frizzed-7 Wnt receptor and the PDZ domain of Dishevelled, down-regulating canonical Wnt signaling and suppressing tumor cell growth. The antitumorigenic effects of FJ9 were pronounced, including induction of apoptosis in human cancer cell lines and tumor growth inhibition in a mouse xenograft model. FJ9 is thus among the first non-peptide inhibitors to show therapeutic efficacy through disruption of PDZ protein-protein interactions."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-2726"xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "He B."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Fujii N."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "You L."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Uematsu K."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Guy R.K."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Neale G."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Shan J."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Mikami I."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Jablons D.M."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/author | "Edmondson L.R."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/pages | "573-579"xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/title | "An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth."xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17234765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17234765 |
| http://purl.uniprot.org/citations/17234765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17234765 |
| http://purl.uniprot.org/uniprot/#_P56704-mappedCitation-17234765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234765 |
| http://purl.uniprot.org/uniprot/#_Q14332-mappedCitation-17234765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234765 |
| http://purl.uniprot.org/uniprot/#_O14640-mappedCitation-17234765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17234765 |