| http://purl.uniprot.org/citations/17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17236236 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositide 3-kinases (PI3K) regulate immune activation via their roles in signal transduction of multiple classes of receptors. Here, we examined the effect of genetic inactivation of the hemopoietic cell-restricted PI3K isoform p110delta on systemic cytokine and chemokine responses and allergic airway inflammation. We found that type 2 cytokine responses (IL-4, IL-5 and IL-13) are significantly decreased in p110delta mutants, whereas type 1 cytokine responses (IFN-gamma and CXCL10) were robust. Elevated IFN-gamma production during the primary response to ovalbumin (OVA) was associated with reduced production of the regulatory cytokine IL-10. IFN-gamma and IL-10 production normalized after secondary OVA immunization; however, type 2 cytokine production was persistently reduced. Type 2 cytokine-dependent airway inflammation elicited by intranasal challenge with OVA was dramatically reduced, with reduced levels of eosinophil recruitment and mucus production observed in the lungs. Induction of respiratory hyper-responsiveness to inhaled methacholine, a hallmark of asthma, was markedly attenuated in p110delta-inactivated mice. Adoptive transfer of OVA-primed splenocytes from normal but not p110delta-inactivated mice could induce airway eosinophilia in naive, airway-challenged recipient mice. These data demonstrate a novel functional role for p110delta signaling in induction of type 2 responses in vivo and may offer a new therapeutic target for Th2-mediated airway disease."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636401"xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Srinivasan G."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Halayko A.J."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Marshall A.J."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Hayglass K.T."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Vanhaesebroeck B."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Okkenhaug K."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Nashed B.F."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/author | "Al-Alwan M."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/pages | "416-424"xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/title | "Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation."xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/17236236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17236236 |
| http://purl.uniprot.org/citations/17236236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17236236 |
| http://purl.uniprot.org/uniprot/#_B0QZL5-mappedCitation-17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17236236 |
| http://purl.uniprot.org/uniprot/#_B1AS24-mappedCitation-17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17236236 |
| http://purl.uniprot.org/uniprot/#_B1AS25-mappedCitation-17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17236236 |
| http://purl.uniprot.org/uniprot/#_B1AS26-mappedCitation-17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17236236 |
| http://purl.uniprot.org/uniprot/#_B1AS27-mappedCitation-17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17236236 |
| http://purl.uniprot.org/uniprot/#_B1AS28-mappedCitation-17236236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17236236 |