| http://purl.uniprot.org/citations/17237514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17237514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17237514 | http://www.w3.org/2000/01/rdf-schema#comment | "The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.106.068148"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.106.068148"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Huang M.C."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Huang M.C."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Reddien P.W."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Reddien P.W."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Andersen E.C."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/author | "Andersen E.C."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/pages | "1719-1733"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/pages | "1719-1733"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/title | "DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/title | "DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/17237514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17237514 |
| http://purl.uniprot.org/citations/17237514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17237514 |