| http://purl.uniprot.org/citations/17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17237936 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have shown the co-existence of alpha-synuclein and phosphorylated tau (pTau) in several neurodegenerative diseases. Here, we report two autopsy cases of combined multiple system atrophy (MSA) and Alzheimer's disease (AD). In both cases, abundant alpha-synuclein-positive glial and neuronal cytoplasmic inclusions were found in the brainstem, amygdala and hippocampal formation. pTau-positive neurofibrillary tangles (NFTs) were widely distributed in case 1 (Braak stage VI) and moderate in case 2 (Braak stage III). Although alpha-synuclein and pTau pathology co-occurred in the hippocampus and entorhinal cortex, only a few neurons showed co-existence of these two proteins. Immunoreactivity for p62, a ubiquitin proteasome system related protein, was found in the majority of NFTs, but in only a small proportion of neuronal alpha-synuclein inclusions. In addition, UBB+1, a mutant form of ubiquitin and a marker for proteasomal dysfunction, was present in the majority of NFTs, whereas co-existence of alpha-synuclein and UBB+1 was found in only a few neurons. These findings indicate that alpha-synuclein and phosphorylated tau co-occur in certain brain regions in cases of combined MSA and AD and that the proteasomal pathways differ between alpha-synuclein- and pTau-bearing neurons."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00401-006-0192-3"xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Ferrer I."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "van Leeuwen F.W."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Terni B."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Torrejon-Escribano B."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Rey M.J."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Boluda S."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Calopa M."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/author | "Sabate M.P."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/name | "Acta Neuropathol"xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/pages | "403-416"xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/title | "Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/17237936 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17237936 |
| http://purl.uniprot.org/citations/17237936 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17237936 |
| http://purl.uniprot.org/uniprot/#_B4DV12-mappedCitation-17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17237936 |
| http://purl.uniprot.org/uniprot/#_B4DE82-mappedCitation-17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17237936 |
| http://purl.uniprot.org/uniprot/#_B4E3V2-mappedCitation-17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17237936 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17237936 |
| http://purl.uniprot.org/uniprot/#_Q13501-mappedCitation-17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17237936 |
| http://purl.uniprot.org/uniprot/#_Q5U5U6-mappedCitation-17237936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17237936 |
| http://purl.uniprot.org/uniprot/P0CG47 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17237936 |