| http://purl.uniprot.org/citations/17239822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17239822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17239822 | http://www.w3.org/2000/01/rdf-schema#comment | "ALS2, the causative gene product for a number of recessive motor neuron diseases, is a guanine-nucleotide exchange factor for Rab5, and acts as a modulator for endosome dynamics. Recently, we have identified a novel ALS2 homolog, ALS2CL, which is highly homologous to the C-terminal half of ALS2. In this study, we investigate the molecular features of ALS2CL and its functional relationship with ALS2. A majority of ALS2CL is present as a homo-dimeric form, which can interact with the ALS2-oligomer, resulting in the formation of the large ALS2/ALS2CL heteromeric complex. In cultured cells, overexpressed ALS2CL is colocalized with ALS2 onto membranous compartments. Further, ALS2CL dominantly suppresses the endosome enlargement induced by a constitutively active form of ALS2, and results in an extensive perinuclear tubulo-membranous phenotype, which are dependent upon the ALS2CL-ALS2 interaction. Collectively, ALS2CL is a novel ALS2-interacting protein and is implicated in ALS2-mediated endosome dynamics."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.12.229"xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.12.229"xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Hadano S."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Hadano S."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Ikeda J.-E."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Ikeda J.-E."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Kunita R."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Kunita R."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Mizumura H."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Mizumura H."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Osuga H."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Osuga H."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Otomo A."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Otomo A."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Suzuki-Utsunomiya K."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/author | "Suzuki-Utsunomiya K."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/pages | "491-497"xsd:string |
| http://purl.uniprot.org/citations/17239822 | http://purl.uniprot.org/core/pages | "491-497"xsd:string |