| http://purl.uniprot.org/citations/17242158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17242158 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF)-D is a secreted glycoprotein that induces angiogenesis and lymphangiogenesis. It consists of a central domain, containing binding sites for VEGF receptor-2 (VEGFR-2) and VEGFR-3, and N- and C-terminal propeptides. It is secreted from the cell as homodimers of the full-length form that can be proteolytically processed to remove the propeptides. It was recently shown, using adenoviral gene delivery, that fully processed VEGF-D induces angiogenesis in vivo, whereas full-length VEGF-D does not. To better understand these observations, we monitored the effect of VEGF-D processing on receptor binding using a full-length VEGF-D mutant that cannot be processed. This mutant binds VEGFR-2, the receptor signaling for angiogenesis, with approximately 17,000-fold lower affinity than mature VEGF-D, indicating the importance of processing for interaction with this receptor. Further, we show that members of the proprotein convertase (PC) family of proteases promote VEGF-D processing, which facilitates the VEGF-D/VEGFR-2 interaction. The PCs furin and PC5 promote cleavage of both propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only. The finding that PCs promote activation of VEGF-D and other proteins with roles in cancer such as matrix metalloproteinases, emphasizes the importance of these enzymes as potential regulators of tumor progression and metastasis."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.06-7060com"xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Harris N.C."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Achen M.G."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Davydova N."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "McColl B.K."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Nice E.C."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Hibbs M.L."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Harder K.W."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Stacker S.A."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Paavonen K."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Karnezis T."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Roufail S."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Rothacker J."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/author | "Rogers P.A."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/pages | "1088-1098"xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/title | "Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2."xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17242158 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17242158 |
| http://purl.uniprot.org/citations/17242158 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17242158 |
| http://purl.uniprot.org/uniprot/#_A0A0U2WZU8-mappedCitation-17242158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242158 |