| http://purl.uniprot.org/citations/17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17242210 | http://www.w3.org/2000/01/rdf-schema#comment | "Myb family proteins are ubiquitously expressed transcription factors. In mammalian cells, they play a critical role in regulating the G(1)/S cell cycle transition but their role in regulating other cell cycle checkpoints is incompletely defined. Herein, we report experiments which demonstrate that c-Myb upregulates cyclin B1 expression in normal and malignant human hematopoietic cells. As a result, it contributes directly to G(2)/M cell cycle progression. In cell lines and primary cells, cyclin B1 levels varied directly with c-Myb expression. Chromatin immunoprecipitation assays, mutation analysis, and luciferase reporter assays revealed that c-Myb bound the cyclin B1 promoter preferentially at a site just downstream of the transcriptional start site. The biological significance of c-Myb, versus B-Myb, binding the cyclin B1 promoter was demonstrated by the fact that expression of inducible dominant negative c-Myb in K562 cells accelerated their exit from M phase. In addition, expression of c-Myb in HCT116 cells rescued cyclin B1 expression after B-myb expression was silenced with small interfering RNA. These results suggest that c-Myb protein plays a previously unappreciated role in the G(2)/M cell cycle transition of normal and malignant human hematopoietic cells and expands the known repertoire of c-myb functions in regulating human hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01100-06"xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Nakata Y."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Sakashita C."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Gewirtz A.M."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Emerson S.G."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Rallapalli R."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Kalota A."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Rudnick S.I."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/author | "Shetzline S."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/pages | "2048-2058"xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/title | "c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression."xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17242210 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17242210 |
| http://purl.uniprot.org/citations/17242210 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17242210 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG19-mappedCitation-17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242210 |
| http://purl.uniprot.org/uniprot/#_Q708E1-mappedCitation-17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242210 |
| http://purl.uniprot.org/uniprot/#_Q708E2-mappedCitation-17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242210 |
| http://purl.uniprot.org/uniprot/#_Q708E3-mappedCitation-17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242210 |
| http://purl.uniprot.org/uniprot/#_Q708E5-mappedCitation-17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242210 |
| http://purl.uniprot.org/uniprot/#_Q708E6-mappedCitation-17242210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242210 |