| http://purl.uniprot.org/citations/17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17242401 | http://www.w3.org/2000/01/rdf-schema#comment | "5-fluorouracil (5-FU) is a widely used chemotherapeutic drug for the treatment of a variety of solid tumors. The anti-tumor activity of 5-FU has been attributed in part to its ability to induce p53-dependent cell growth arrest and apoptosis. However, the molecular mechanisms underlying p53 activation by 5-FU remain largely obscure. Here we report that 5-FU treatment leads to p53 stabilization and activation by blocking MDM2 feedback inhibition through ribosomal proteins. 5-FU treatment increased the fraction of ribosome-free L5, L11, and L23 ribosomal proteins and their interaction with MDM2, leading to p53 activation and G1/S arrest. Conversely, individual knockdown of these ribosomal proteins by small interfering RNA prevented the 5-FU-induced p53 activation and reversed the 5-FU-induced G1/S arrest. These results demonstrate that 5-FU treatment triggers a ribosomal stress response so that ribosomal proteins L5, L11, and L23 are released from ribosome to activate p53 by ablating the MDM2-p53 feedback circuit."xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m610621200"xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/author | "Dai M.S."xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/author | "Sun X.X."xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/pages | "8052-8059"xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/title | "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction."xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17242401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17242401 |
| http://purl.uniprot.org/citations/17242401 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A346XLN8-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A346XLS8-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_A0A346XLT4-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_D5KL86-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_E2G6R5-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |
| http://purl.uniprot.org/uniprot/#_Q1HGV3-mappedCitation-17242401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17242401 |