| http://purl.uniprot.org/citations/17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17255092 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian SWI/SNF complex is an evolutionarily conserved ATP-dependent chromatin remodeling complex that consists of nine or more components. SRG3, a murine homologue of yeast SWI3, Drosophila MOIRA, and human BAF155, is a core component of the murine SWI/SNF complex required for the regulation of transcriptional processes associated with development, cellular differentiation, and proliferation. Here we report that SRG3 interacts directly with other components of the mammalian SWI/SNF complex such as SNF5, BRG1, and BAF60a. The SWIRM domain and the SANT domain were required for SRG3-SNF5 and SRG3-BRG1 interactions, respectively. In addition, SRG3 stabilized SNF5, BRG1, and BAF60a by attenuating their proteasomal degradation, suggesting its general role in the stabilization of the SWI/SNF complex. Such a stabilization effect of SRG3 was not only observed in the in vitro cell system, but also in cells isolated from SRG3 transgenic mice or knock-out mice haploinsufficient for the Srg3 gene. Taken together, these results suggest the critical role of SRG3 in the post-transcriptional stabilization of the major components of the SWI/SNF complex."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m610563200"xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Oh J."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Sohn D.H."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Chung H."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Seong R.H."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/author | "Jeon S.H."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/pages | "10614-10624"xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/title | "SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17255092 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17255092 |
| http://purl.uniprot.org/citations/17255092 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17255092 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J170-mappedCitation-17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17255092 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFJ8-mappedCitation-17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17255092 |
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| http://purl.uniprot.org/uniprot/#_A0A2R8VI28-mappedCitation-17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17255092 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VKP3-mappedCitation-17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17255092 |
| http://purl.uniprot.org/uniprot/#_F6U415-mappedCitation-17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17255092 |
| http://purl.uniprot.org/uniprot/#_D6RDC4-mappedCitation-17255092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17255092 |