| http://purl.uniprot.org/citations/17259380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17259380 | http://www.w3.org/2000/01/rdf-schema#comment | "Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficient (SR-A(-/-)) mice. Diabetes was induced in SR-A(-/-) and wild-type (SR-A(+/+)) mice by streptozotocin injection. Diabetic SR-A(+/+) mice presented characteristic features of diabetic nephropathy: albuminuria, glomerular hypertrophy, mesangial matrix expansion, and overexpression of transforming growth factor-beta at 6 months after induction of diabetes. These changes were markedly diminished in diabetic SR-A(-/-) mice, without differences in blood glucose and blood pressure levels. Interestingly, macrophage infiltration in the kidneys was dramatically decreased in diabetic SR-A(-/-) mice compared with diabetic SR-A(+/+) mice. DNA microarray revealed that proinflammatory genes were overexpressed in renal cortex of diabetic SR-A(+/+) mice and suppressed in diabetic SR-A(-/-) mice. Moreover, anti-SR-A antibody blocked the attachment of monocytes to type IV collagen substratum but not to endothelial cells. Our results suggest that SR-A promotes macrophage migration into diabetic kidneys by accelerating the attachment to renal extracellular matrices. SR-A may be a key molecule for the inflammatory process in pathogenesis of diabetic nephropathy and a novel therapeutic target for diabetic vascular complications."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.org/dc/terms/identifier | "doi:10.2337/db06-0359"xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Makino H."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Okada S."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Sasaki M."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Takeya M."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Kido Y."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Horiuchi S."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Ogawa D."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Ohga S."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Wada J."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Shikata K."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Tone A."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Shikata Y."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Nagase R."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Takeya M.'"xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Usui H.K."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/author | "Yozai K."xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/pages | "363-372"xsd:string |
| http://purl.uniprot.org/citations/17259380 | http://purl.uniprot.org/core/title | "Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation."xsd:string |