| http://purl.uniprot.org/citations/17260967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17260967 | http://www.w3.org/2000/01/rdf-schema#comment | "Leucine-rich repeat kinase 2 (LRRK2), a product of a causative gene for the autosomal-dominant form of familial Parkinson's disease (PARK8), harbors a Ras-like small GTP binding protein-like (ROC) domain besides the kinase domain, although the relationship between these two functional domains remains elusive. Here we show by thin-layer chromatographic analysis that LRRK2 stably binds GTP but lacks a GTPase activity in HEK293 and Neuro-2a cells. A ROC domain mutation that converts LRRK2 to a guanine nucleotide-free form (T1348N) abolishes the kinase activity of LRRK2 as well as its phosphate incorporation upon metabolic labeling. The phosphorylation of LRRK2 was inhibited by potential inhibitors for cyclic AMP-dependent protein kinase. These data suggest that binding of GTP to the ROC domain regulates the kinase activity of LRRK2 as well as its phosphorylation by other kinase(s)."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi061960m"xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Iwatsubo T."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Katada T."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Okai T."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Ito G."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/author | "Fujino G."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/pages | "1380-1388"xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/title | "GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/17260967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17260967 |
| http://purl.uniprot.org/citations/17260967 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17260967 |
| http://purl.uniprot.org/uniprot/Q5S007#attribution-2719E86199DE0FAAD308B16DFC57CE29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/#_A0A218N881-mappedCitation-17260967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/#_A2VED2-mappedCitation-17260967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/#_Q17RV3-mappedCitation-17260967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/#_Q6MZN9-mappedCitation-17260967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/#_Q5S007-mappedCitation-17260967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/A0A218N881 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17260967 |
| http://purl.uniprot.org/uniprot/Q5S007 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17260967 |