| http://purl.uniprot.org/citations/17264082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17264082 | http://www.w3.org/2000/01/rdf-schema#comment | "It is well accepted that high levels of high density lipoproteins (HDL) reduce the risk of atherosclerosis in humans. Apolipoprotein A-I (apoA-I) and apoA-II are the first and second most common protein constituents of HDL. Unlike apoA-I, detailed structural models for apoA-II in HDL are not available. Here, we present a structural model of apoA-II in reconstituted HDL (rHDL) based on two well established experimental approaches: chemical cross-linking/mass spectrometry (MS) and internal reflection infrared spectroscopy. Homogeneous apoA-II rHDL were reacted with a cross-linking agent to link proximal lysine residues. Upon tryptic digestion, cross-linked peptides were identified by electrospray mass spectrometry. 14 cross-links were identified and confirmed by tandem mass spectrometry (MS/MS). Infrared spectroscopy indicated a beltlike molecular arrangement for apoA-II in which the protein helices wrap around the lipid bilayer rHDL disc. The cross-links were then evaluated on three potential belt arrangements. The data clearly refute a parallel model but support two antiparallel models, especially a "double hairpin" form. These models form the basis for understanding apoA-II structure in more complex HDL particles."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m610380200"xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/author | "Davidson W.S."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/author | "Axelsen P.H."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/author | "Schneeweis L.A."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/author | "Krishnan S.C."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/author | "Silva R.A.G.D."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/pages | "9713-9721"xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/title | "The structure of apolipoprotein A-II in discoidal high density lipoproteins."xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17264082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17264082 |
| http://purl.uniprot.org/citations/17264082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17264082 |
| http://purl.uniprot.org/uniprot/P02652#attribution-68C3F68DC1F1BB37B160C653084DA0C7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17264082 |
| http://purl.uniprot.org/uniprot/#_Q76EI7-mappedCitation-17264082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17264082 |
| http://purl.uniprot.org/uniprot/#_P02652-mappedCitation-17264082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17264082 |
| http://purl.uniprot.org/uniprot/#_V9GYT0-mappedCitation-17264082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17264082 |
| http://purl.uniprot.org/uniprot/P02652 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17264082 |
| http://purl.uniprot.org/uniprot/Q76EI7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17264082 |
| http://purl.uniprot.org/uniprot/V9GYT0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17264082 |