| http://purl.uniprot.org/citations/17266347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17266347 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify apoptotic targets of HtrA2/Omi, we purified recombinant HtrA2/Omi and its catalytically inactive S306A mutant. Lysates of human Jurkat T lymphocytes incubated with either wild-type recombinant HtrA2/Omi or the S306A mutant were screened using the gel-free COFRADIC approach that isolates peptides covering the N-terminal parts of proteins. Analysis of the 1162 proteins identified by mass spectrometry yielded 15 HtrA2/Omi substrates of potential physiological relevance together holding a total of 50 cleavage sites. Several processing events were validated by incubating purified recombinant HtrA2/Omi with in vitro translated substrates or with Jurkat cell lysates. In addition, the generated set of cleavage sites was used to assess the protein substrate specificity of HtrA2/Omi. Our results suggest that HtrA2/Omi has a rather narrow cleavage site preference and that cytoskeletal proteins are prime targets of this protease."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.org/dc/terms/identifier | "doi:10.1021/pr060510d"xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Gevaert K."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Vandekerckhove J."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Van Damme P."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Saelens X."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Lamkanfi M."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/author | "Vande Walle L."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/name | "J Proteome Res"xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/pages | "1006-1015"xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/title | "Proteome-wide Identification of HtrA2/Omi Substrates."xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/17266347 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17266347 |
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