| http://purl.uniprot.org/citations/17267501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17267501 | http://www.w3.org/2000/01/rdf-schema#comment | "Infections with RNA viruses are sensed by the innate immune system through membrane-bound Toll-like receptors or the cytoplasmic RNA helicases RIG-I and MDA-5. It is believed that MDA-5 is crucial for sensing infections by picornaviruses, but there have been no studies on the role of this protein during infection with poliovirus, the prototypic picornavirus. Beginning at 4 h postinfection, MDA-5 protein is degraded in poliovirus-infected cells. Levels of MDA-5 declined beginning at 6 h after infection with rhinovirus type 1a or encephalomyocarditis virus, but the protein was stable in cells infected with rhinovirus type 16 or echovirus type 1. Cleavage of MDA-5 is not carried out by either poliovirus proteinase 2Apro or 3Cpro. Instead, degradation of MDA-5 in poliovirus-infected cells occurs in a proteasome- and caspase-dependent manner. Degradation of MDA-5 during poliovirus infection correlates with cleavage of poly(ADP) ribose polymerase (PARP), a hallmark of apoptosis. Induction of apoptosis by puromycin leads to cleavage of both PARP and MDA-5. The MDA-5 cleavage product observed in cells treated with puromycin is approximately 90 kDa, similar in size to the putative cleavage product observed in poliovirus-infected cells. Poliovirus-induced cleavage of MDA-5 may be a mechanism to antagonize production of type I interferon in response to viral infection."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01360-06"xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Gupta P."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Racaniello V.R."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Barral P.M."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Morrison J.M."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/author | "Drahos J."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/pages | "3677-3684"xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/title | "MDA-5 is cleaved in poliovirus-infected cells."xsd:string |
| http://purl.uniprot.org/citations/17267501 | http://purl.uniprot.org/core/volume | "81"xsd:string |
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