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| http://purl.uniprot.org/citations/17267561 | http://www.w3.org/2000/01/rdf-schema#comment | "The cacophony (cac) locus in Drosophila encodes a Ca2+ channel alpha subunit, but little is known about properties of cac-mediated currents and functional consequences of cac mutations in central neurons. We found that, in Drosophila cultured neurons, Ca2+ currents were mediated predominantly by the cac channels. The cac channels contribute to low- and high-threshold, fast- and slow-inactivating types of Ca2+ currents, take part in membrane depolarization, and strongly activate Ca2+-activated K+ current [I(K(Ca))]. In cac neurons, unexpectedly, voltage-activated transient K+ current I(A) is upregulated to a level that matches I(K(Ca)) reduction, implicating a homeostatic regulation that was mimicked by chronic pharmacological blockade of Ca2+ currents in wild-type neurons. Among K+ channel transcripts, Shaker mRNA levels were preferentially increased in cac flies. However, Ca2+ current expression levels remained unaltered in several K+ channel mutants, illustrating a key role of cac in developmental regulation of Drosophila neuronal excitability."xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4746-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/author | "Wu C.F."xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/author | "Peng I.F."xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/pages | "1072-1081"xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/title | "Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation."xsd:string |
| http://purl.uniprot.org/citations/17267561 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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