| http://purl.uniprot.org/citations/17272411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17272411 | http://www.w3.org/2000/01/rdf-schema#comment | "Genotypic associations between polymorphisms in the ciliary neurotrophic factor (CNTF) and CNTF receptor (CNTFR) genes and muscular strength phenotypes in 154 middle-aged men (45-49 yr) and 138 women (38-44 yr) and 99 older men (60-78 yr) and 102 older women (60-80 yr) were tested to validate earlier association studies. Allelic interaction effects were hypothesized between alleles of CNTF and CNTFR. We performed analysis of covariance with age, height, and fat-free mass (FFM) as covariates. FFM was anthropometrically estimated by the equation of Durnin-Womersley. Isometric, concentric, and eccentric torques for the knee flexors (KF) and extensors (KE) were measured using Biodex dynamometry. In the older male group, T-allele carriers of the C-1703T polymorphism in CNTFR performed significantly better on all noncorrected KF torques, whereas only noncorrected KE isometric torque at 120 degrees and concentric torque at 240 degrees/s were higher than the C/C homozygotes (P < 0.05). When age, height, and FFM were used as covariates, T-allele carriers performed only better on KE and KF isometric torque at 120 degrees (P < 0.05). Concentric KF torque at 180 degrees/s was lower in middle-aged female A-allele carriers compared with the T/T subjects for the T1069A polymorphism in CNTFR. After correction for age, height, and FFM, middle-aged female A-allele carriers exhibited lower values on all concentric KF strength measures and isometric torque at 120 degrees . There was a lack of association with the CNTF G-6A polymorphism in men, with inconclusive results for a limited number of phenotypes in women. No significant CNTF/CNTFR allele interaction effects were found. Results indicate that CNTFR C-1703T and T1069A polymorphisms are significantly associated with muscle strength in humans."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.org/dc/terms/identifier | "doi:10.1152/japplphysiol.00692.2006"xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/author | "Lefevre J."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/author | "Thomis M.A."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/author | "Beunen G."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/author | "De Mars G."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/author | "Delecluse C."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/author | "Windelinckx A."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/name | "J Appl Physiol (1985)"xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/pages | "1824-1831"xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/title | "Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women."xsd:string |
| http://purl.uniprot.org/citations/17272411 | http://purl.uniprot.org/core/volume | "102"xsd:string |
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