| http://purl.uniprot.org/citations/17273999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17273999 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of interferon regulatory factor (IRF)-3 and/or IRF-7 drives the expression of antiviral genes and the production of alpha/beta IFN, a hallmark of antiviral responses triggered by Toll-like receptors (TLR). Here we describe a novel antiviral signaling pathway operating in myeloid (m) dendritic cells (DC) and macrophages that does not require IRF-3 and/or IRF-7 but is driven by IRF-1. IRF-1 together with myeloid differentiation factor 88 (MyD88) or IL-1 receptor-associated kinase (IRAK)-1 triggered IFN-beta promoter activation. IRF-1 physically interacted with MyD88 and activation of mDC via TLR-9 induced IRF-1-dependent IFN-beta production paralleled by rapid transcriptional activation of IFN-stimulated genes. The NF-kappaB-dependent production of pro-inflammatory cytokines, however, was not influenced by IRF-1. TLR-9 signaling through this pathway conferred cellular antiviral resistance while IRF-1-deficient mice displayed enhanced susceptibility to viral infection. These results demonstrate that TLR-9 activation of mDC and macrophages contributes to antiviral immunity via IRF-1."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636767"xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Krug A."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Adler H."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Lang R."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Drexler I."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Guggemoos S."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Schmitz F."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Wagner H."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Haas T."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Schiemann M."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Mages J."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/author | "Heit A."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/pages | "315-327"xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/title | "Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/17273999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17273999 |
| http://purl.uniprot.org/citations/17273999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17273999 |
| http://purl.uniprot.org/uniprot/#_A0A140LHC2-mappedCitation-17273999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17273999 |
| http://purl.uniprot.org/uniprot/#_P15314-mappedCitation-17273999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17273999 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-17273999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17273999 |
| http://purl.uniprot.org/uniprot/#_A0A140LHE6-mappedCitation-17273999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17273999 |