| http://purl.uniprot.org/citations/17276355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17276355 | http://www.w3.org/2000/01/rdf-schema#comment | "The Cdk7/cyclin H/ménage-à-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by Gq-, calcineurin-, and biomechanical stress-dependent pathways for hypertrophic growth. Using cardiac-specific Cre, we have ablated MAT1 in myocardium. Despite reduced Cdk7 activity, MAT1-deficient hearts grew normally, but fatal heart failure ensued at 6-8 weeks. By microarray profiling, quantitative RT-PCR, and western blotting at 4 weeks, genes for energy metabolism were found to be suppressed selectively, including targets of peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1). Cardiac metabolic defects were substantiated in isolated perfused hearts and isolated mitochondria. In culture, deleting MAT1 with Cre disrupted PGC-1 function: PGC-1alpha failed to activate PGC-1-responsive promoters and nuclear receptors, GAL4-PGC-1alpha was functionally defective, and PGC-1beta was likewise deficient. PGC-1 bound to both MAT1 and Cdk7 in coprecipitation assays. Thus, we demonstrate a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2007.01.003"xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Izumi Y."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Asakura M."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Sano M."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Shimizu N."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Xie M."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Hu L."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Makela T.P."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Taegtmeyer H."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Graham B.H."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Scaglia F."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Schneider M.D."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Boudina S."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Rossi D.J."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Kralli A."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Wilson C.R."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Abel E.D."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Pautler R.G."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Taffet G."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/author | "Helenius K."xsd:string |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17276355 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |