| http://purl.uniprot.org/citations/17277128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17277128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17277128 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-19, IL-20, IL-22, IL-24, and IL-26 are members of the IL-10 family of cytokines that have been shown to be up-regulated in psoriatic skin. Contrary to IL-10, these cytokines signal using receptor complex R1 subunits that are preferentially expressed on cells of epithelial origin; thus, we henceforth refer to them as the IL-20 subfamily cytokines. In this study, we show that primary human keratinocytes (KCs) express receptors for these cytokines and that IL-19, IL-20, IL-22, and IL-24 induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner. These cytokines also induce expression of the psoriasis-associated protein S100A7 and keratin 16 in RHE and cause persistent activation of Stat3 with nuclear localization. IL-22 had the most pronounced effects on KC proliferation and on the differentiation of KCs in RHE, inducing a decrease in the granular cell layer (hypogranulosis). Furthermore, gene expression analysis performed on cultured RHE treated with these cytokines showed that IL-19, IL-20, IL-22, and IL-24 regulate many of these same genes to variable degrees, inducing a gene expression profile consistent with inflammatory responses, wound healing re-epithelialization, and altered differentiation. Many of these genes have also been found to be up-regulated in psoriatic skin, including several chemokines, beta-defensins, S100 family proteins, and kallikreins. These results confirm that IL-20 subfamily cytokines are important regulators of epidermal KC biology with potentially pivotal roles in the immunopathology of psoriasis."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.4.2229"xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.4.2229"xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Zhong F."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Zhong F."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Jung K."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Jung K."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Hall L."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Hall L."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Modrusan Z."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Modrusan Z."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Ouyang W."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Ouyang W."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Valdez P.A."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Valdez P.A."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Danilenko D.M."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Danilenko D.M."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Winer J."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Winer J."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Kasman I."xsd:string |
| http://purl.uniprot.org/citations/17277128 | http://purl.uniprot.org/core/author | "Kasman I."xsd:string |