| http://purl.uniprot.org/citations/17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17287278 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection by Kaposi's sarcoma-associated herpesvirus (KSHV) is required for the development of Kaposi's sarcoma (KS), a highly inflammatory angiogenic tumor of endothelial cells commonly found in untreated AIDS patients. Angiopoietin 2 (Ang-2) modulates the vasculature during inflammation and angiogenesis, but the mechanism by which KSHV regulates Ang-2 expression has not been investigated. Here, we show that KSHV infection of primary human umbilical vein endothelial cells induced the expression and release of Ang-2, which in turn was required for KSHV-induced paracrine-dependent angiogenesis in vivo. Ang-2 was strongly expressed in small vessels and spindle tumor cells in KS tumors. Mechanistically, KSHV activated the Ang-2 promoter via AP-1 and Ets1 transcriptional factors, which were mediated by ERK, JNK, and p38 mitogen-activated protein kinase (MAPK) pathways. Our findings demonstrate the importance of Ang-2 in KS angiogenesis and define a novel role for AP-1 and MAPK pathways in regulating angiogenesis. This study also illustrates a distinct mechanism by which a tumor virus modulates vasculature to promote tumorigenesis and exemplifies the convergence of oncogenesis and angiogenesis pathways in tumor development."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02089-06"xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Blackbourn D.J."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Gao S.J."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Graham D."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Ye F.C."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Greene W."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Mengel M."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Yeh I.T."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Qian L.W."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/author | "Xie J.P."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/pages | "3980-3991"xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/title | "Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1."xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17287278 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17287278 |
| http://purl.uniprot.org/citations/17287278 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17287278 |
| http://purl.uniprot.org/uniprot/#_A8K725-mappedCitation-17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287278 |
| http://purl.uniprot.org/uniprot/#_B2R6E3-mappedCitation-17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287278 |
| http://purl.uniprot.org/uniprot/#_B4DW78-mappedCitation-17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287278 |
| http://purl.uniprot.org/uniprot/#_O15123-mappedCitation-17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287278 |
| http://purl.uniprot.org/uniprot/#_P14921-mappedCitation-17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287278 |
| http://purl.uniprot.org/uniprot/#_Q6FG54-mappedCitation-17287278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287278 |