| http://purl.uniprot.org/citations/17287827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17287827 | http://www.w3.org/2000/01/rdf-schema#comment | "The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. We have used a model of infection with coxsackievirus B3 (CVB3) to characterize the contribution of host genetics to viral myocarditis in mice of different genetic backgrounds but with a common H2 haplotype: A/J and B10.A-H2(a). Here we have used Evans blue dye as a quantitative biomarker for susceptibility to CVB3-induced myocarditis in addition to histopathological semiquantitative measures. We have found evidence of linkage between susceptibility to viral myocarditis and three loci. A locus on chromosome 1 centered on D1Mit200 was linked to sarcolemmal disruption in males (P=0.00005), a second locus on chromosome 4 centered on D4Mit81 was also linked to sarcolemmal disruption in males (P=0.0022). A third locus on distal chromosome 3 centered on D3Mit19 was linked to myocardial infiltration, with a logarithm of odds (LOD) score of 4.7 (P=0.0045), as well as sarcolemmal disruption in females (P=0.0015). These results provide strong evidence for the presence of loci contributing to the susceptibility of mice to viral myocarditis."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6364374"xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/author | "Wiltshire S."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/author | "Vidal S.M."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/author | "Aly M."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/author | "Chahrour G."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/author | "Osti J.C."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/pages | "193-204"xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/title | "Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis."xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/17287827 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17287827 |
| http://purl.uniprot.org/citations/17287827 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17287827 |
| http://purl.uniprot.org/uniprot/#_A0A087WQP1-mappedCitation-17287827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287827 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-17287827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287827 |
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| http://purl.uniprot.org/uniprot/#_Q3TH80-mappedCitation-17287827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287827 |