| http://purl.uniprot.org/citations/17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17287858 | http://www.w3.org/2000/01/rdf-schema#comment | "The spectrum of CBFB-MYH11 fusion transcripts in acute myeloid leukemia (AML) M4eo with inv(16)/t(16;16) is heterogeneous. Approximately 85% show type A CBFB-MYH11 fusion transcripts. In addition, more than 10 different fusion transcripts have been reported. The prognostic impact and biological background of rare fusion transcripts remain open. In this study, a molecular characterization of CBFB-MYH11 transcripts in 162 patients with CBFB-MYH11 positive AML at diagnosis was performed. In total, 128 patients (79.0%) showed the fusion transcript type A, whereas nine different rare CBFB-MYH11 fusion genes were detected in 34 cases (21.0%). Rare fusion transcripts were found more frequently in therapy-related AML (P=0.0106). Numerical gains of the chromosomes 8, 21 and 22 were more frequently associated with type A (28.3%) than with rare fusions (12.9%) (P=0.012). Median white blood cell (WBC) count was higher in type A (35.4 G/l; range=1.1-279 G/l) than in cases with rare types (7.8 G/l; range=0.8-148.0 G/l) (P<0.0001). Rare fusion transcripts were correlated with an atypical cytomorphology not primarily suggestive for the FAB subtype M4eo (P=0.0203). Immunophenotype revealed lower CD2, CD13, CD33 and CD90 levels than in type A fusion cases (P=0.036, 0.002, 0.029 and 0.045, respectively). However, the type of fusion was not an independent prognostic parameter."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.leu.2404531"xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/author | "Schnittger S."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/author | "Bacher U."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/author | "Haferlach T."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/author | "Kern W."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/author | "Haferlach C."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/pages | "725-731"xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/title | "Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patients."xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17287858 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17287858 |
| http://purl.uniprot.org/citations/17287858 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17287858 |
| http://purl.uniprot.org/uniprot/#_A0A024QZJ4-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_A8K719-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_B1PS43-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_O14729-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_O14794-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_Q13951-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_P35749-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_Q16085-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_Q16086-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |
| http://purl.uniprot.org/uniprot/#_Q66K75-mappedCitation-17287858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17287858 |