| http://purl.uniprot.org/citations/17289029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17289029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17289029 | http://www.w3.org/2000/01/rdf-schema#comment | "To gain insight into the mechanism by which Gli-similar 2 (Glis2) regulates transcription, we performed yeast-two hybrid cDNA library screening using Glis2 as bait. This screening identified beta-catenin as a potential Glis2-interacting protein. Mammalian two-hybrid, co-immunoprecipitation, and GST-pulldown analyses supported the interaction between Glis2 and beta-catenin. Pulldown analyses with several Glis2 deletion mutants indicated that the 1st zinc finger motif of Glis2 is critical for its interaction with beta-catenin, while the armadillo repeats of beta-catenin are important in its interaction with Glis2. Reporter analyses showed that Glis2 represses T-cell factor (TCF)-mediated transcriptional activation. In addition, Glis2 represses the expression of the TCF target gene cyclin D1. Our results indicate that Glis2 interacts with beta-catenin and suggest that Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.01.058"xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.01.058"xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/author | "Kim Y.-S."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/author | "Kim Y.-S."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/author | "Kang H.S."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/author | "Kang H.S."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/author | "Jetten A.M."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/author | "Jetten A.M."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/pages | "858-864"xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/pages | "858-864"xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/title | "The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/title | "The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/volume | "581"xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://purl.uniprot.org/core/volume | "581"xsd:string |
| http://purl.uniprot.org/citations/17289029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17289029 |
| http://purl.uniprot.org/citations/17289029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17289029 |
| http://purl.uniprot.org/citations/17289029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17289029 |
| http://purl.uniprot.org/citations/17289029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17289029 |