| http://purl.uniprot.org/citations/17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17290223 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies demonstrated that proinflammatory migration inhibitory factor(MIF) blocks p53-dependent apoptosis and interferes with the tumor suppressor activity of p53. To explore the mechanism underlying this MIF-p53 relationship, we studied spontaneous tumorigenesis in genetically matched p53-/- and MIF-/-p53-/-mice. We show that the loss of MIF expression aggravates the tumor-prone phenotype of p53-/-mice and predisposes them to a broader tumor spectrum, including B-cell lymphomas and carcinomas. Impaired DNA damage response is at the root of tumor predisposition of MIF-/-p53-/-mice. We provide evidence that MIF plays a role in regulating the activity of Cul1-containing SCF ubiquitin ligases. The loss of MIF expression uncouples Chk1/Chk2-responsive DNA damage checkpoints from SCF-dependent degradation of key cell-cycle regulators such as Cdc25A, E2F1 and DP1, creating conditions for the genetic instability of cells. These MIF effects depend on its association with the Jab1/CSN5 subunit of the COP9/CSN signalosome. Given that CSN plays a central role in the assembly of SCF complexes in vivo, regulation of Jab1/CSN5 by MIF is required to sustain optimal composition and function of the SCF complex."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601564"xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/author | "Petrenko O."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/author | "Mena P."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/author | "Fingerle-Rowson G."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/author | "Nemajerova A."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/author | "Moll U.M."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/pages | "987-997"xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/title | "Impaired DNA damage checkpoint response in MIF-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17290223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17290223 |
| http://purl.uniprot.org/citations/17290223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17290223 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUW1-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_D3YWC5-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_D3Z2H3-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_D3YUS8-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_O14757-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_O35280-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_P34884-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |
| http://purl.uniprot.org/uniprot/#_G3UYC5-mappedCitation-17290223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17290223 |