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| http://purl.uniprot.org/citations/17292338 | http://www.w3.org/2000/01/rdf-schema#comment | "Serum IL-18 responses to LPS increase after pretreatment with CpG-containing DNA. Compared to saline-pretreated controls, mice pretreated with CpG for two days produced 20-fold more serum IL-18 when challenged with lipopolysaccharide (LPS). In contrast, IFNgamma-deficiency or anti-IFNgamma pretreatment reduced CpG-expanded IL-18 responses to LPS by 67 and 83%, respectively. Mice pretreated with either IFNgamma or CpG comparably increased LPS-inducible serum IL-18 responses. LPS, compared to challenge with other TLR agonists, was best able to trigger high serum IL-18 levels in CpG-pretreated mice and this response was TLR4-dependent. CpG, compared to pretreatment with other TLR agonists, optimally expanded LPS-induced IL-18 responses that correlated with higher levels of circulating IFNgamma levels prior to LPS challenge. High-level serum IL-18 responses were caspase-1-dependent and P2X7 receptor-independent. We conclude that CpG promotes high-level IL-18 synthesis by an IFNgamma-dependent and IFNgamma-sufficient mechanism in vivo that is optimally triggered by LPS."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2006.12.004"xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/author | "Canaday D.H."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/author | "Heinzel F.P."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/author | "Auletta J.J."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/author | "Gould M.P."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/author | "DeVecchio J."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/pages | "75-82"xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/title | "CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo."xsd:string |
| http://purl.uniprot.org/citations/17292338 | http://purl.uniprot.org/core/volume | "243"xsd:string |
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